Top Ten Reviews website put out a review of the top ten genealogy software programs of 2012. You can read the results here.
I use the two tied for first place: Family Tree Maker 2012 with Sync, and Legacy. Because of the Sync feature that works with Ancestry online, and also the incredible collections of records, and also their seamless partnership with My Canvas, where I can create a genealogy book using the records in my tree at Ancestry.com, I am using FTM 2012 almost exclusively this year.
The third of the top ten programs is Roots Magic. I have investigated the screens and the features, and appreciate the color coded family trees, but it isn't enough to beat out the time saving features of Sync.
Whatever your choice, I strongly recommend buying the best manual available to go with your program. Being able to look up how to do something in a reference manual has saved me hours of time and frustration.